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Accession Number PB2013-110769
Title Report on Carcinogens (RoC) Concept: Cumene.
Publication Date 2013
Media Count 10p
Personal Author N/A
Abstract Cumene (CASRN 98-82-8, isopropylbenzene) is an alkylated benzene found in fossil fuels, such as blended gasoline and kerosene, and products of incomplete combustion (IARC2012). It has a gasoline-like odor and can exist as a vapor in ambient air. Cumene is structurally similar to benzene, toluene, styrene, xylene, and ethylbenzene. It is a high production volume chemical in the United States with the majority of its use in the synthesis of acetone and phenol. Cumene has been selected as a candidate substance for the RoC based on widespread current U.S. exposure and an adequate database of cancer studies. Exposure to cumene comes from the use of fossil fuels, solvents, and cigarette smoke. The National Toxicology Program (NTP) completed a series of cumene inhalation toxicology and carcinogenesis studies (NTP 2009) and disposition and metabolism studies in rats and mice.
Keywords Alkylated benzene
Fossil fuels
National Toxicology Program(NTP)

Source Agency National Institute of Environmental Health Sciences
NTIS Subject Category 57Y - Toxicology
99B - Industrial Chemistry & Chemical Process Engineering
97K - Fuels
68A - Air Pollution & Control
44F - Health Care Forecasting Methodology
Corporate Author National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Document Type Technical report
Title Note N/A
NTIS Issue Number 1325
Contract Number N/A

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