|
Accession Number
|
DE2012-1035856
|
|
Title
|
High Resolution Monolithic Crystal, DOI, MR Compatible, PET Detector.
|
|
Publication Date
|
Mar 2012
|
|
Media Count
|
8p
|
|
Personal Author
|
R. Miyaoka
|
|
Abstract
|
The principle objective of this proposal is to develop a positron emission tomography (PET) detector with depth-of-interaction (DOI) positioning capability that will achieve state of the art spatial resolution and sensitivity performance for small animal PET imaging. When arranged in a ring or box detector geometry, the proposed detector module will support <1 mm3 image resolution and >15% absolute detection efficiency. The detector will also be compatible with operation in a MR scanner to support simultaneous multi-modality imaging. The detector design will utilize a thick, monolithic crystal scintillator readout by a two-dimensional array of silicon photomultiplier (SiPM) devices using a novel sensor on the entrance surface (SES) design. Our hypothesis is that our single-ended readout SES design will provide an effective DOI positioning performance equivalent to more expensive dual-ended readout techniques and at a significantly lower cost. Our monolithic crystal design will also lead to a significantly lower cost system. It is our goal to design a detector with state of the art performance but at a price point that is affordable so the technology can be disseminated to many laboratories. A second hypothesis is that using SiPM arrays, the detector will be able to operate in a MR scanner without any degradation in performance to support simultaneous PET/MR imaging. Having a co-registered MR image will assist in radiotracer localization and may also be used for partial volume corrections to improve radiotracer uptake quantitation. The far reaching goal of this research is to develop technology for medical research that will lead to improvements in human health care.
|
|
Keywords
|
Animals
Crystals
Design
Detection
Efficiency
Geometry
Hypothesis
Phosphors
Photomultipliers
Positioning
Positron emission tomography
Prices
Resolution
Sensitivity
Sensors
Silicon
Spatial resolution
|
|
|
Source Agency
|
Technical Information Center Oak Ridge Tennessee
|
|
NTIS Subject Category
|
46 - Physics
57V - Radiobiology
|
|
Corporate Author
|
Washington Univ., Seattle.
|
|
Document Type
|
Technical report
|
|
Title Note
|
N/A
|
|
NTIS Issue Number
|
1303
|
|
Contract Number
|
DE-FG02-08ER64676
|
