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Accession Number DE2012-1032741
Title High Resolution PET with 250-Micrometer LSO Detectors and Adaptive Zoom.
Publication Date Sep 2011
Media Count 6p
Personal Author J. Qi S. Cherry
Abstract There have been impressive improvements in the performance of small-animal positron emission tomography (PET) systems since their first development in the mid 1990s, both in terms of spatial resolution and sensitivity, which have directly contributed to the increasing adoption of this technology for a wide range of biomedical applications. Nonetheless, current systems still are largely dominated by the size of the scintillator elements used in the detector. Our research predicts that developing scintillator arrays with an element size of 250 im or smaller will lead to an image resolution of 500 im when using 18F- or 64Cu-labeled radiotracers, giving a factor of 4-8 improvement in volumetric resolution over the highest resolution research systems currently in existence. This proposal had two main objectives: (i) To develop and evaluate much higher resolution and efficiency scintillator arrays that can be used in the future as the basis for detectors in a small-animal PET scanner where the spatial resolution is dominated by decay and interaction physics rather than detector size. (ii) To optimize one such high resolution, high sensitivity detector and adaptively integrate it into the existing microPET II small animal PET scanner as a zoom-in detector that provides higher spatial resolution and sensitivity in a limited region close to the detector face. The knowledge gained from this project will provide valuable information for building future PET systems with a complete ring of very high-resolution detector arrays and also lay the foundations for utilizing high-resolution detectors in combination with existing PET systems for localized high-resolution imaging.
Keywords Animals
Decay
Detectors
Images
Performance
Phosphors
Positron computed tomography
Positrons
Resolution
Sensitiivity
Spatial resolution
Tomography

 
Source Agency Technical Information Center Oak Ridge Tennessee
NTIS Subject Category 46 - Physics
57V - Radiobiology
Corporate Author California Univ., Davis.
Document Type Technical report
Title Note N/A
NTIS Issue Number 1309
Contract Number DE-FG02-08ER64677

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