Accession Number DE2012-1032061
Title Simplication of Methods for PET Radiopharmaceutical Syntheses.
Publication Date 2011
Media Count 3p
Personal Author M. R. Kilbourn
Abstract In an attempt to develop simplified methods for radiochemical synthesis of radiopharmaceuticals useful in Positron Emission Tomography (PET), current commercially available automated synthesis apparati were evaluated for use with solid phase synthesis, thin-film techniques, microwave-accelerated chemistry, and click chemistry approaches. Using combinations of these techniques, it was shown that these automated synthesis systems can be simply and effectively used to support the synthesis of a wide variety of carbon-11 and fluorine-18 labeled compounds, representing all of the major types of compounds synthesized and using all of the common radiochemical precursors available. These techniques are available for use to deliver clinically useful amounts of PET radiopharmaceuticals with chemical and radiochemical purities and high specific activities, suitable for human administration.
Keywords Carbon 11
Chemical compounds
Evaluation
Fluorine 18
Positron computed tomography
Radiochemistry
Radiopharmaceuticals
Solid phases
Synthesis(Chemistry)
Thin films

 
Source Agency Technical Information Center Oak Ridge Tennessee
NTIS Subject Category 57V - Radiobiology
57E - Clinical Medicine
99E - Photochemistry and Radiation Chemistry
Corporate Author Michigan Univ., Ann Arbor.
Document Type Technical report
Title Note N/A
NTIS Issue Number 1307
Contract Number DE-FG02-08ER64645

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