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Accession Number ADA584091
Title Early Post Traumatic Seizures in Military Personnel Result in Long Term Disability.
Publication Date Oct 2012
Media Count 16p
Personal Author P. M. Vespa
Abstract This study is predicated on substantial evidence that early post- traumatic seizures occur frequently and create a metabolic crisis that will lead to cell death of hippocampal tissue among persons who have sustained a traumatic brain injury (TBI). Our central hypothesis is that early post- traumatic seizures are acutely injurious due to increases in intracranial pressure and acute edema of the hippocampus leading to delayed long term hippocampal atrophy. This represents a unique translational hypothesis that we are uniquely qualified to study. In this study we plan to perform continuous EEG monitoring of military and civilian TBI patients for the initial 7 days after TBI to assess for non-convulsive seizures. This is followed by evaluating these same subjects at 6 months after injury by volumetric MRI of the hippocampus and cognitive testing to assess for disturbances of memory-related cognition and post-traumatic stress. We have begun to study civilian TBI patients in year 1 and have worked on establishing methodology and connectivity and IRB permission at military sites in year 1.
Keywords Atrophy
Convulsive disorders
Military facilities
Military personnel
Physical disabilities
Post traumatic stress disorder
Test and evaluation
Wounds and injuries

Source Agency Non Paid ADAS
NTIS Subject Category 92B - Psychology
57T - Psychiatry
57E - Clinical Medicine
70D - Personnel Management, Labor Relations & Manpower Studies
74 - Military Sciences
Corporate Author California Univ., Los Angeles. School of Medicine.
Document Type Technical report
Title Note Annual rept. 15 Sep 2011-14 Sep 2012.
NTIS Issue Number 1402
Contract Number W81XWH-08-2-0699

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