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Accession Number ADA583513
Title Measuring Intracranial Pressure and Correlation with Severity of Blast Traumatic Brain Injury.
Publication Date Jan 2013
Media Count 64p
Personal Author P. J. VandeVord
Abstract A greater understanding of the mechanism(s) of TBI due from overpressure exposure is critical to develop effective protection and treatments. Fundamental, yet unresolved, questions concern the mode of blast energy transfer to the brain as well as the consequent damage or disruptive mechanisms at the cellular level. The ultimate goal of this research effort is to determine the intracranial pressure (ICP) responses to blast exposure. The objective of this research is to understand how pressure is transmitted through the brain and ascertain the relationship between levels of pressure transmission with severity of brain injury. Injury severity parameters were investigated during this year of the proposal. We used a shock tube model in which non-instrumented animals were be subjected to a single shock wave. Groups of animals were subjected to a different magnitude of overpressure. We present several neurological outcomes and neuropathologies that are unique to each pressure group. Overall, the large amount of data indicates molecular changes that occur depending on blast energy level.
Keywords Blast
Energy levels
Energy transfer
Shock tubes
Shock waves
Traumatic brain injuries

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
79E - Detonations, Explosion Effects, & Ballistics
Corporate Author Army Medical Research and Materiel Command (Provisional), Fort Detrick, MD.
Document Type Technical report
Title Note Final rept. 16 Sep 2008-15 Dec 2012.
NTIS Issue Number 1401
Contract Number W81XWH-08-2-0207

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