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Accession Number ADA583479
Title Fatty Acid Synthesis and Control of Caspase 2 in Prostate Cancer.
Publication Date May 2013
Media Count 7p
Personal Author S. Kornbluth
Abstract Although prostate cancers are initially responsive to androgen deprivation therapy, castration resistant prostate cancer demands alternative treatment options. It has been reported that the apoptotic protease, caspase 2 (C2) is critical for prostate cancer cell death in several settings. Several reports have also indicated that fatty acid synthesis is critical for maintaining prostate cancer cell viability and that inhibition of fatty acid synthesis can lead to apoptosis. Finally, C2 is suppressed by high intracellular NADPH and this is not due to the redox effects of NADPH, suggesting that the synthetic role of NADPH (e.g., in fatty acid synthesis) may account for its ability to suppress apoptosis. Our new data suggest that manipulating metabolism, particularly inhibiting fatty acid synthesis, can alter chemosensitivity in prostate cancer cells.
Keywords Acids
Androgens
Cells(Biology)
Death
Deprivation
Fatty acids
Inhibition
Oxidation reduction reactions
Peptide hydrolases
Prostate cancer
Prostate gland
Reports
Resistance(Biology)
Synthesis(Chemistry)
Testes
Therapy

 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Duke Univ., Durham, NC. School of Medicine.
Document Type Technical report
Title Note Final rept. 1 Jul 2011-30 Jun 2012.
NTIS Issue Number 1401
Contract Number W81XWH-11-1-0290

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