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Accession Number ADA583374
Title Role of Rho GTPases in Breast Cancer Migration and Invasion.
Publication Date Apr 2013
Media Count 7p
Personal Author J. Smith
Abstract Rho-family GTPases are the major regulators of the actin and microtubule cytoskeleton. Regulators of the GTPases include GEFs and GAPs, which control activation and deactivation, respectively, of this family of molecular switches. This study explores the role of the GEF Tiam2 in breast cancer cell proliferation and invasion, which was initially discovered using a siRNA screen in MDA-MB-231 breast cancer cells. Protein expression studies are performed using a panel of cell lines, revealing that Tiam2 expression is upregulated in Ras mutant cells. Additionally, Tiam2 depletion causes MDA-MB- 231 cells to form fewer colonies in soft agar colony formation assays. A specific role for Tiam2 in tumor formation and proliferation in mouse models remains to be elucidated. This work adds insight into the molecular mechanisms by which cancer cells invade into surrounding tissue and eventually result in death.
Keywords Breast cancer
Cells(Biology)
Gtpase
Muscle proteins
Mutations
Rho
Tiam2


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Sloan-Kettering Inst. for Cancer Research, New York.
Document Type Technical report
Title Note Revised annual summary rept. 15 March 2010 14 March 2013.
NTIS Issue Number 1401
Contract Number W81XWH-10-1-0164

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