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Accession Number ADA583193
Title Novel Therapeutic Strategy for the Prevention of Bone Fractures.
Publication Date Jun 2013
Media Count 82p
Personal Author M. W. Hamrick
Abstract Falls and debilitating bone fractures are a major problem for veterans, and more than 40,000 veterans suffered hip fractures from 2000-2002. Falls are the main etiological factor in more than 90% of fractures, and so treatments that can improve muscle strength while at the same time increasing bone mass will significantly reduce fracture-related morbidity and mortality. Myostatin is a factor that induces muscle wasting and suppresses bone formation. Our data collected thus far demonstrate: (i) myostatin suppresses proliferation of aged, but not young, myoblasts, (ii) myostatin is elevated with age in muscles composed primarily of slow-twitch fibers (e.g. soleus), and (iii) myostatin increases muscle mass and muscle fiber size in aged mice. These findings suggest that myostatin inhibitors may have potential for suppressing muscle wasting and improving muscle repair in older individuals, but their effect on bone may be less significant.
Keywords Aging
Bone fractures
Etiology
Fractures
Hip
Inhibitors
Muscles
Osteoporosis
Preventive medicine
Repair
Strength(Physiology)
Therapy


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Medical Coll. of Georgia, Augusta.
Document Type Technical report
Title Note Final rept. 15 May 2010-14 May 2013.
NTIS Issue Number 1401
Contract Number W81XWH-10-1-0365

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