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Accession Number ADA583192
Title Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells.
Publication Date Mar 2013
Media Count 56p
Personal Author A. Nussenzweig
Abstract Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.
Keywords Breast cancer
Cancer biology
Cells(Biology)
Dna repair
Genome
Instability
Life span(Biology)
Molecular properties
Therapy
Tumorigenesis

 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Geneva Foundation, Lakewood, WA.
Document Type Technical report
Title Note Annual rept. 1 Mar 2012-28 Feb 2013.
NTIS Issue Number 1401
Contract Number W81XWH-11-1-0106

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