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Accession Number ADA583166
Title Prenatal Development Effects of Carbon Dioxide (CO2) Exposure in Rats (Rattus Norvegicus).
Publication Date Oct 2012
Media Count 35p
Personal Author B. Wong K. S. Bynum M. Okolica R. A. James W. R. Howard
Abstract Female rats were exposed to clean air or 1.5%, 2.0%, 2.5%, or 3.0% carbon dioxide (CO2) gas for approximately 23 hr/day from GD6-20 of pregnancy. There were no remarkable post-exposure findings in adults, including no differences in bodyweight or food consumption. There were no remarkable post-exposure findings in fetal bodyweight, and no malformations or developmental variations following CO2 exposure. There were two statistically significant findings in the 3.0% CO2 group: a higher mean post-implantation loss per litter (early resorptions) and a corresponding lower mean proportion of viable fetuses per litter. These results yield a No Observed Adverse Effect Level (NOAEL) of 2.5% and a Lowest Observed Adverse Effect Level (LOAEL) of 3.0% for CO2. Using the 2.5% NOAEL as a point of departure for a developing a CEL and an interspecies uncertainty factor of 3 yields a recommended CEL of 0.8% for CO2. Developmental endpoints are assumed to result from a single day of exposure during gestation; therefore, the 24-hour EEL is also recommended to be made 0.8% CO2. These recommendations should not outweigh any other studies that may derive a lower recommendation based on relevant data and endpoints.
Keywords Absorption
Adults
Adverse conditions
Carbon dioxide
Developmental toxicology
Dioxides
Exposure in utero
Females
Fetus
Food consumption
Gases
Implantation loss
Inhalation
Prenatal development
Rats
Rattus norvegicus
Toxicology


 
Source Agency Non Paid ADAS
NTIS Subject Category 57C - Botany
57Z - Zoology
57Y - Toxicology
99D - Basic & Synthetic Chemistry
Corporate Author Naval Medical Research Inst. Dayton, Wright Patterson AFB, OH.
Document Type Technical report
Title Note Technical rept. Dec 2011-Oct 2012.
NTIS Issue Number 1401
Contract Number FAD 00004

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