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Accession Number ADA582936
Title Assessment of Geographical Variation in the Respiratory Toxicity of Desert Dust Particles.
Publication Date 2013
Media Count 13p
Personal Author E. Fornero J. A. Centeno J. M. Law K. Taylor M. L. Foster
Abstract The health consequences of sand particle inhalation are incompletely understood. This project evaluated the respiratory toxicity of sand particles collected at military bases near Fort Irwin USA, in Iraq (Camp Victory, Taji and Talil), and Khost Afghanistan. Our primary focus was on assessing the role of soluble metals in the respiratory toxicity of the sand particles using in vitro and in vivo methods. Replicating rat type II alveolar cell cultures (RLE- 6TN) were exposed to sand extracts or vehicle control in serum-free media for 24 h. Cytotoxicity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay and assessment of lactate dehydrogenase leakage.
Keywords Cytotoxicity
Dust
Dust inhalation
Geography
In vitro analysis
In vivo analysis
Lung
Particle toxicity
Particles
Pulmonary toxicity
Rats
Respiratory system
Sand
Toxicity


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
48F - Geology & Geophysics
Corporate Author Naval Research Lab., Washington, DC. Center for Biomolecular Science and Engineering.
Document Type Journal article
Title Note Journal article.
NTIS Issue Number 1401
Contract Number W911QY-08-P-0473

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