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Accession Number ADA582729
Title Family-Based Exercise Intervention for Children and Adolescents with Prader-Willi Syndrome.
Publication Date Oct 2012
Media Count 82p
Personal Author D. A. Rubin D. J. Driscoll D. J. Rose J. Weiss K. Wilson
Abstract Physical activity (PA) holds strong potential as a non- pharmacological therapeutic approach to complement the management of Prader- Willi Syndrome (PWS). Since childhood obesity is an escalating problem associated with multiple maladies, providing alternative PA intervention strategies is vital. We have developed an at-home PA intervention titled Active Play at Home. We expect improvements in motor coordination, sensory integration, body composition, and quality of life in participants. We have enrolled 62 families at CSUF as of 9/14/2012. Our preliminary findings demonstrate high compliance (approximately 88%) with the intervention in most participants. We have also demonstrated that the Bruininks-Oseretsky Test of Motor Proficiency is a reliable instrument to evaluate motor function in individuals with PWS. We have been able to identify seven distinct nutritional phases in individuals with PWS. We have also shown that hyperghrelinemia begins in early infancy in PWS and decreases as the individual gets older. Therefore, ghrelin is unlikely to be the 'key player' in the increased appetite found in individuals with PWS.
Keywords Biochemistry
Bmr(Basal metabolic rate)
Bruininks-oseretsky test of motor proficiency
Cardiovascular diseases
Crp(C- reactive protein)
Decision making
Motor function
Nutritional phases
Physical activity
Pws(Prader-willi syndrome)
Tnf-a(Tumor-necrosis factor alpha)

Source Agency Non Paid ADAS
NTIS Subject Category 57B - Biochemistry
57A - Anatomy
57S - Physiology
57E - Clinical Medicine
57L - Nutrition
98H - Food Technology
57W - Stress Physiology
Corporate Author California State Univ., Fullerton.
Document Type Technical report
Title Note Annual rept. 15 Sep. 2011-14 Sep. 2012.
NTIS Issue Number 1401
Contract Number W81XWH-09-1-0682

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