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Accession Number ADA582694
Title Photonic Breast Tomography and Tumor Aggressiveness Assessment.
Publication Date Jul 2012
Media Count 35p
Personal Author F. B. Lin J. A. Koutcher M. Alrubaiee R. R. Alfano S. K. Gayen
Abstract The tasks performed and the progresses made during the fourth year include the following: (1) carrying out research on the development of noninvasive near-infrared (NIR) diffuse optical imaging (DOI) approaches for the detection of breast tumors in the early stages of growth when they are more amenable to treatment; and (2) training of CCNY researchers at MSKCC in magnetic resonance spectroscopic imaging (MRSI) for the detection of lactate in tumors. The NIR optical imaging research involved the development of time reversal optical tomography (TROT) for imaging single absorbing and single scattering targets as a function of position, and two targets as a function of separation between them; and the adaptation and comparison of Principal Component Analysis (PCA) and Nonnegative Matrix Factorization (NMF) methods to the DOI problem and comparing them with previously developed OPTICA (optical tomography using independent component analysis). These approaches were demonstrated to be suited for detecting and locating small targets in tissue- simulating turbid media. MRSI investigation of lactate holds promise for assessment of tumor aggressiveness. We also have initiated the development of numerical algorithms for fluorescence tomography, since it has the potential to provide higher contrast as well as molecular and functional information through the use of exogenous fluorophores. A new research pre-proposal was developed and submitted to CDMRP 2011 BCRP Idea Award category for funding.
Keywords Breast cancer
Finite element analysis
Fluorescence tomography
Independent component analysis
Infrared images
Magnetic resonance imaging
Magnetic resonance spectroscopic imaging
Mammary glands
Near infrared radiation
Near-infrared diffuse optical imaging
Near-infrared imaging
Optical detection
Principal component analysis
Time reversal optical tomography

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
63C - Infrared & Ultraviolet Detection
46C - Optics & Lasers
Corporate Author City Univ. of New York. Research Foundation.
Document Type Technical report
Title Note Annual summary 15 Jun 2011-14 Jun 2012.
NTIS Issue Number 1401
Contract Number W81XWH-07-1-0454

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