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Accession Number ADA575955
Title Tumor Microenvironment and Progression to Invasion after a Diagnosis of Ductal Carcinoma In Situ.
Publication Date Mar 2013
Media Count 11p
Personal Author A. Trentham-Dietz P. J. Keely
Abstract Ductal carcinoma in situ (DCIS) makes up 18% of all new breast cancer diagnoses, and is considered a precursor to invasive breast cancer even though the majority of cases almost 70% may never progress to invasive disease. Markers that identify which patients are most likely to experience progression are critically needed so that fewer patients are over-treated. This study is evaluating two novel tumor markers that may indicate greater risk of tumor progression based on recent work that suggests that stromal syndecan-1 expression induces an extracellular matrix with aligned collagen fiber architecture, and that this collagen alignment in turn facilitates malignant cell invasion. We are using archived tumor tissue from 267 cases of DCIS of the breast to evaluate syndecan-1 expression and collagen alignment. These DCIS cases, diagnosed between 1995 and 1999, have been followed for breast cancer outcomes; to-date, 13% of cases have experienced a second breast cancer diagnosis. Analysis of syndecan-1 expression and collagen alignment patterns will be completed soon, and preliminary data analysis has begun. Findings from this research are expected to be disseminated through peer-reviewed journals and for presentation at national conferences by the end of the year.
Keywords Breast cancer
Collagen alignment
Disease-free survival
Ductal carcinoma in situ
Mammary glands
Peer groups
Tumor microenvironment

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Wisconsin Univ.-Madison.
Document Type Technical report
Title Note Annual rept. 1 Mar 2012-28 Feb 2013.
NTIS Issue Number 1319
Contract Number W81XWH-11-1-0214

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