Accession Number ADA575953
Title Defining Platelet Function During Polytrauma.
Publication Date Feb 2013
Media Count 16p
Personal Author D. F. Brophy
Abstract Hemostasis is arguably the highest treatment priority for the polytraumatized patient. Best hemostasis practices cannot be developed if we lack a more full understanding of the cell-based clotting system during trauma. In order to address this fundamental knowledge gap, this study will provide a comprehensive characterization of the most important cellular component of the coagulation system, the platelet. The study proposes a comprehensive characterization of platelet function over time in civilian victims of polytrauma that may inform development of new diagnostic, therapeutic, and clinical guidelines for hemorrhage control and treatment of coagulopathy in trauma. We have successfully developed a comprehensive panel of tests to include: 1. Platelet aggregation by aggregometry under conditions of low and high shear stress and in response to collagen and ADP stimulation, 2. Platelet- associated thrombin generation using calibrated automated thrombography, 3. Platelet-induced clot contraction and using viscoelastic measures such as TEG with Platelet Mapping and, 4. Flow cytometry for platelet receptor and white cell activation as well as circulating platelet and platelet-monocyte aggregates. These panels are being coupled with a comprehensive data base of trauma victim demographics, diagnostics, and therapeutics to define the relationships between platelet function and injury pattern/severity, tissue hypoperfusion, transfusion, traumatic brain injury, inflammation, and clinical outcomes.
Keywords Blood platelets
Brain
Calibration
Casualties
Clinical medicine
Data bases
Data processing
Diagnosis(Medicine)
Hemorrhage
Inflammation
Intravascular clots
Leukocytes
Patients
Platelet function
Platelet receptor activation
Polytrauma
Response
Sense organs
Stimulation(Physiology)
Thromboelastography
Tissues(Biology)
Trauma
Viscoelasticity
Wounds and injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Virginia Commonwealth Univ., Richmond.
Document Type Technical report
Title Note Revised annual rept. 10 Jan 2012-9 Jan 2013.
NTIS Issue Number 1319
Contract Number W81XWH-11-2-0089

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