Accession Number ADA575824
Title CINRG: Systems Biology of Glucocorticoids in Muscle Disease.
Publication Date Oct 2012
Media Count 14p
Personal Author Z. Wang
Abstract We developed two computational network reconstruction methods, linear state space model and dynamic Bayesian network to infer transcriptional networks using the rat acute transcriptional time series of bolus administration of glucocorticoids. And this time series was re-profiled using Illumina gene expression BeadChip for a much broader coverage. We have tested multiple repeated injection models for inducing asynchronous regeneration in normal mouse muscles. Based on the analysis of injured muscles, we found that the reinjury model with 10 days in between two injuries lead to pathological damages that most closely resemble the muscle pathology observed in untreated mdx muscles and human DMD muscles. We are using the 10 day reinjury model to induce asynchronous regeneration in normal mouse muscles, and are using glucocorticoids to treat the injured muscles. Based on part of the work accomplished in this grant, we have been awarded several new grants focusing on studying glucocorticoid mechanism in treating DMD and asthma.
Keywords Adrenal cortex hormones
Asynchronous systems
Diseases
Drug mechanism
Duchenne muscular dystrophy
Genes
Glucocorticoids
Humans
Linear systems
Muscles
Networks
Pathology
Regeneration(Physiology)
Systems biology
Wounds and injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
57W - Stress Physiology
Corporate Author Army Medical Research and Materiel Command (Provisional), Fort Detrick, MD.
Document Type Technical report
Title Note Annual rept. 21 Sep 2011-20 Sep 2012.
NTIS Issue Number 1319
Contract Number W81XWH-09-1-0726

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