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Accession Number ADA575806
Title Functional Role of MicroRNAs in Hematopoietic Stem Cells in the Myelodysplastic Syndromes.
Publication Date May 2012
Media Count 45p
Personal Author C. Y. Park
Abstract Myelodysplastic syndromes (MDS) are acquired bone marrow failure disorders characterized by poor clinical outcomes due to progressively worsening blood cell counts (especially red blood cells) and increased risk of developing leukemia. MDS originates in hematopoietic stem cells (HSC), but there is little information available regarding the molecular mechanisms regulating MDS HSC function. We have characterized the expression of more than 750 microRNAs in MDS HSC purified from MDS patient samples and compared their expression to normal, age-matched controls. These studies identify at least 31 microRNAs that are differentially expressed in MDS HSC compared to normal controls (FDR > 0.1, P < 0.05). We have initiated studies to characterize the potential role of these microRNAs in MDS pathogenesis by using a combination of in vitro assays and a newly developed xenograft model of MDS. Our findings are consistent with a role of miRNAs in MDS HSC function and future studies will aim to validate the role of each of these candidate miRNAs in MDS development and progression.
Keywords Acute myeloid leukemia
Blood cells
Blood counts
Bone marrow
Clinical medicine
Hematopoietic cells
Hsc(Hematopoietic stem cells)
In vitro analysis
Mds(Myelodysplastic syndromes)
Preclinical model
Ribonucleic acids
Ribosomal protein
Signs and symptoms
Stem cells
Surgical transplantation

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57F - Cytology, Genetics, & Molecular Biology
Corporate Author Sloan-Kettering Inst. for Cancer Research, New York.
Document Type Technical report
Title Note Annual rept. 1 May 2011-30 Apr 2011.
NTIS Issue Number 1319
Contract Number W81XWH-11-1-0288

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