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Accession Number ADA575734
Title Nanofiber Nerve Guide for Peripheral Nerve Repair and Regeneration.
Publication Date Jan 2013
Media Count 10p
Personal Author A. Hoke H. Mao
Abstract The primary goal of this collaborative research project is to develop next generation engineered nerve guide conduits (NGCs) with aligned nanofibers and favorable release kinetics of neurotrophic factors to help improve surgical outcomes after injuries involving peripheral nerves. In the second year of the work, we further improved the gradient loading of the neurotrophic factor GDNF (Glial cell derived neurotrophic factor) and tested various combinations of NGCs in a rat sciatic nerve regeneration model. We have also started the IACUC application for the large animal validation study using the peroneal nerve repair in dogs.
Keywords Dogs
Gradient loading
Nanofiber nerve guides
Nerve regeneration
Neurotrophic factor
Wounds and injuries

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Johns Hopkins Univ., Baltimore, MD.
Document Type Technical report
Title Note Revised annual rept. 3 Dec 2011-2 Dec 2012.
NTIS Issue Number 1319
Contract Number W81XWH-11-2-0047

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