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Documents in the NTIS Technical Reports collection are the results of federally funded research. They are directly submitted to or collected by NTIS from Federal agencies for permanent accessibility to industry, academia and the public.  Before purchasing from NTIS, you may want to check for free access from (1) the issuing organization's website; (2) the U.S. Government Printing Office's Federal Digital System website; (3) the federal government Internet portal; or (4) a web search conducted using a commercial search engine such as
Accession Number ADA574962
Title Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer.
Publication Date Oct 2012
Media Count 26p
Personal Author A. Zhang
Abstract In the year-2, we advanced our understandings regarding the challenges of trans-rectal fluorescence diffuse optical tomography (FDOT) of negative-contrast targets, for prostate cancer detection by using zinc-specific fluorescent probe. The challenges are evaluated through analytical, numerical, and experimental methods. Specifically, we developed a novel analytical approach to quantify diffuse photon propagation in an outward-imaging geometry that idealizes imaging prostate tissue by using transrectal optical applicator. we demonstrated numerically that DOT/FDOT measurements is less sensitive to a negative-contrast target than to a positive-contrast target, and detecting a target of negative-contrast in the trans-rectal prostate-imaging geometry is especially challenging. we conducted trans-rectal ultrasound-coupled FDOT of tissue phantoms containing target of positive or negative fluorescent contrast over the background. 'Negative-contrast' target is found very challenging to reconstruct.
Keywords Diffuse optical tomography
Fluorescence diffuse optical tomography
Optical properties
Prostate cancer
Prostate gland

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
99D - Basic & Synthetic Chemistry
Corporate Author Oklahoma State Univ., Stillwater.
Document Type Technical report
Title Note Annual summary rept. 15 Sep 2011-14 Sep 2012.
NTIS Issue Number 1319
Contract Number W81XWH-10-1-0836

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