Accession Number ADA574962
Title Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer.
Publication Date Oct 2012
Media Count 26p
Personal Author A. Zhang
Abstract In the year-2, we advanced our understandings regarding the challenges of trans-rectal fluorescence diffuse optical tomography (FDOT) of negative-contrast targets, for prostate cancer detection by using zinc-specific fluorescent probe. The challenges are evaluated through analytical, numerical, and experimental methods. Specifically, we developed a novel analytical approach to quantify diffuse photon propagation in an outward-imaging geometry that idealizes imaging prostate tissue by using transrectal optical applicator. we demonstrated numerically that DOT/FDOT measurements is less sensitive to a negative-contrast target than to a positive-contrast target, and detecting a target of negative-contrast in the trans-rectal prostate-imaging geometry is especially challenging. we conducted trans-rectal ultrasound-coupled FDOT of tissue phantoms containing target of positive or negative fluorescent contrast over the background. 'Negative-contrast' target is found very challenging to reconstruct.
Keywords Diffuse optical tomography
Fluorescence diffuse optical tomography
Optical properties
Prostate cancer
Prostate gland

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
99D - Basic & Synthetic Chemistry
Corporate Author Oklahoma State Univ., Stillwater.
Document Type Technical report
Title Note Annual summary rept. 15 Sep 2011-14 Sep 2012.
NTIS Issue Number 1319
Contract Number W81XWH-10-1-0836

Science and Technology Highlights

See a sampling of the latest scientific, technical and engineering information from NTIS in the NTIS Technical Reports Newsletter

Acrobat Reader Mobile    Acrobat Reader