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Accession Number ADA574962
Title Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer.
Publication Date Oct 2012
Media Count 26p
Personal Author A. Zhang
Abstract In the year-2, we advanced our understandings regarding the challenges of trans-rectal fluorescence diffuse optical tomography (FDOT) of negative-contrast targets, for prostate cancer detection by using zinc-specific fluorescent probe. The challenges are evaluated through analytical, numerical, and experimental methods. Specifically, we developed a novel analytical approach to quantify diffuse photon propagation in an outward-imaging geometry that idealizes imaging prostate tissue by using transrectal optical applicator. we demonstrated numerically that DOT/FDOT measurements is less sensitive to a negative-contrast target than to a positive-contrast target, and detecting a target of negative-contrast in the trans-rectal prostate-imaging geometry is especially challenging. we conducted trans-rectal ultrasound-coupled FDOT of tissue phantoms containing target of positive or negative fluorescent contrast over the background. 'Negative-contrast' target is found very challenging to reconstruct.
Keywords Diffuse optical tomography
Diffusion
Fluorescence
Fluorescence diffuse optical tomography
Geometry
Images
Optical properties
Photons
Propagation
Prostate cancer
Prostate gland
Sensitivity
Tissues(Biology)
Tomography
Zinc


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
99D - Basic & Synthetic Chemistry
Corporate Author Oklahoma State Univ., Stillwater.
Document Type Technical report
Title Note Annual summary rept. 15 Sep 2011-14 Sep 2012.
NTIS Issue Number 1319
Contract Number W81XWH-10-1-0836

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