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Accession Number ADA574474
Title Global Epigenetic Changes May Underlie Ethnic Differences and Susceptibility to Prostate Cancer.
Publication Date Sep 2012
Media Count 22p
Personal Author B. Kwabi-Addo
Abstract The incidence and mortality of prostate cancer (PCa) is approximately 2 fold higher in African American (AA) than in European-American (EA) men. This disparity is believed to be a complex combination of environment, socioeconomic factors and genetics. The purpose of the present study is to study genome wide DNA methylation changes in prostate biospecimens from AA and EA men in order to elucidating the epigenetic DNA methylation changes associated with prostate cancer disparity and identify novel biomarkers for early disease detection. RESULTS: In our preliminary genome-wide methylation studies, we examined the methylation status of Infunium 450K (484,968) CpG sites that corresponds to 21,221 genes in microarray (illumina) analysis. In all, we selected 25 promoter associated novel CpG sites that were differentially methylated in correlation with prostate cancer progression from benign to HGPIN to prostate cancer (FDR adjusted p- value).
Keywords African americans
Ethnic groups
Genetic engineering
Mortality rate
Prostate cancer

Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
92C - Social Concerns
57S - Physiology
57E - Clinical Medicine
Corporate Author Howard Univ., Washington, DC.
Document Type Technical report
Title Note Annual rept. 26 Aug 2011-25 Aug 2012.
NTIS Issue Number 1318
Contract Number W81XWH-11-1-0567

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