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Accession Number ADA571105
Title Glycomic Analysis of Prostate Cancer.
Publication Date Jul 2012
Media Count 17p
Personal Author R. Goldman
Abstract We are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. Newly optimized methods for the glycomic analysis of proteins fractionated into three components are in place. We have assembled the study population and completed the glycomic analysis in two fractions; analysis of the IgA/IgM fraction is under way. We have also evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis identified some connections to glycosylation. The final analysis and the interpretation of results is ongoing.
Keywords Aa(African american)
African americans
Ea(European american)
Gene expression
Glycomic analysis
Health disparity
Prostate cancer
Protein glycosylation
Ribonucleic acids

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57F - Cytology, Genetics, & Molecular Biology
Corporate Author Georgetown Univ., Washington, DC.
Document Type Technical report
Title Note Final rept. 1 Jul 2009-30 Jun 2012.
NTIS Issue Number 1315
Contract Number W81XWH-09-1-0202

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