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Accession Number ADA570991
Title TRNA and Its Activation Targets as Biomarkers and Regulators of Breast Cancer. Revision.
Publication Date Sep 2012
Media Count 8p
Personal Author M. Rosner T. Pan
Abstract Breast cancer refers to a variety of types that each derive from distinct causes and merit different treatments. It is crucial to develop new classes of molecules that target heretofore unexplored cellular mechanisms, so that tumors not responsive to current treatments might be responsive to new routes of therapy. We are exploring a previously under-appreciated avenue that can lead to precise identification of breast cancer sub-types to improve treatment options and identify new therapeutic targets. The genetic code is decoded by transfer RNA (tRNA). We discovered that breast tumors have high levels of tRNA and tRNA over-expression has an aberrant pattern suggesting that tumors use tRNA over-expression to mis-regulate the synthesis of some crucial proteins. Further, we found that a specific tRNAis an on cogene in breast cells suggesting that tRNA over-expression could even originate the development of breast cancer. We are identifying the mis-regulation targets of tRNA over- expression in breast cancer to serve as biomarkers and establishing the potential of targeting tRNA as a new route for breast cancer treatment.
Keywords Abnormalities
Breast cancer
Mammary glands
Ribonucleic acids

Source Agency Non Paid ADAS
NTIS Subject Category 57F - Cytology, Genetics, & Molecular Biology
57E - Clinical Medicine
Corporate Author Chicago Univ., IL.
Document Type Technical report
Title Note Revised final rept. 1 Sep 2010-31 Aug 2012.
NTIS Issue Number 1315
Contract Number W81XWH-10-1-0453

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