Accession Number ADA570968
Title Novel RNA Helicase Inhibitor to Treat Breast Cancer.
Publication Date Aug 2012
Media Count 6p
Personal Author V. Raman Y. Kato
Abstract In this funding cycle, we concentrated on encapsulating NZ51 into nanoparticles that are biocompatible and biodegradable. Earlier, we had reported that we were successful in preparing PLGA nanoparticles loaded with GdDTPA -BOA and superparamagnetic iron oxide (SPIO) nanoparticles. Based on that technology, we initiated experiments to load PLGA nanoparticles with NZ51. After a series of experiments, we concluded that there was significant variation from batch to batch preparation and we have to refine the technology used. Currently, we are attempting to encapsulate the RNA helicase inhibitor into a different nanoparticle, such as PLGA nanoparticles composed of low molecular weight copolymers, or nanoparticles composed of chitosan derivatives, with the goals of achieving a faster release resulting in increased efficacy for breast cancer treatment. Also, we are in the process to determine why the different batches made have different aggregation properties in mouse plasma. Furthermore, we are attempting to encapsulate a different DDX3 inhibitor into PLGA nanoparticle to evaluate if the chemical structure of NZ51 is in anyway interfering with the formulation and utility in in vivo experiments.
Keywords Batch processing
Breast cancer
Copolymers
Cycles
Formulations
Helicase
In vivo analysis
Inhibitors
Mammary glands
Molecular structure
Molecular weight
Plasmas(Physics)
Ribonucleic acids


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57F - Cytology, Genetics, & Molecular Biology
Corporate Author Johns Hopkins Univ., Baltimore, MD.
Document Type Technical report
Title Note Annual rept. 1 Aug 2011-31 Jul 2012.
NTIS Issue Number 1315
Contract Number W81XWH-10-1-0603

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