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Accession Number ADA570602
Title Defining Genomic Changes in Triple-Negative Breast Cancer in Women of African Descent.
Publication Date Jun 2012
Media Count 12p
Personal Author L. L. Baumbach M. Pegram
Abstract Breast cancer (BC) is the second leading cause of cancer death among African-American (AA) women, with mortality 20% greater than that in Caucasians (Cauc). However, the basis for such disparity remains an enigma. Recent observations from our laboratory suggest the involvement of unidentified genes contributing to AA BC risk. Matched tumor and normal FFPE samples from Cauc and AA patients were obtained from the UM/Sylvester Breast Tissue Bank (UM/S BTB) under an IRB-approved protocol. Based on analysis of 22,000 transcripts, ethnic specific gene expression patterns were identified that may provide important new insights into molecular mechanisms of ethnic subtype differences in clinical outcomes. We propose to extend these preliminary findings to a large African tumor bank available via collaboration between Drs. Peter A. Bird (Kijabe, Kenya) and Mark Pegram (UM Sylvester). Additionally, we propose to analyze chromosomal alterations associated with gene expression differences utilizing array cGH (in collaboration with Alan Ashworth, England). This work will contribute to development of rationale designs of preventive, predictive and therapeutic measures for BC in different ethnicities, and thus, a significant reduction in current ethnic-specific disparities in BC incidence, morbidity and mortality.
Keywords Africa
African americans
Array cgh
Breast cancer
Change detection
Deoxyribonucleic acids
Ethnic disparities
Gene expression profiling
Mammary glands
Molecular properties
Mortality rate
Tissue banks
Triple negative breast cancer

Source Agency Non Paid ADAS
NTIS Subject Category 70D - Personnel Management, Labor Relations & Manpower Studies
92A - Job Training & Career Development
57E - Clinical Medicine
Corporate Author Miami Univ., FL.
Document Type Technical report
Title Note Annual rept. 1 Jun 2011-31 May 2012.
NTIS Issue Number 1315
Contract Number W81XWH-09-1-0068

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