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Accession Number ADA570590
Title Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury.
Publication Date Sep 2012
Media Count 16p
Personal Author R. J. Nudo
Abstract A small, lightweight microdevice has been developed for activity- dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with TBI using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microdevice) and open-loop stimulation (OLS) rats. Specifically, open-loop stimulation does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury.
Keywords Anesthesia
Open loop systems
Traumatic brain injuries

Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Kansas Univ. Medical Center, Kansas City.
Document Type Technical report
Title Note Annual rept. 1 Sep 2011-31 Aug 2012.
NTIS Issue Number 1315
Contract Number W81XWH-10-1-0742

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