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Documents in the NTIS Technical Reports collection are the results of federally funded research. They are directly submitted to or collected by NTIS from Federal agencies for permanent accessibility to industry, academia and the public.  Before purchasing from NTIS, you may want to check for free access from (1) the issuing organization's website; (2) the U.S. Government Printing Office's Federal Digital System website http://www.gpo.gov/fdsys; (3) the federal government Internet portal USA.gov; or (4) a web search conducted using a commercial search engine such as http://www.google.com.
Accession Number ADA570587
Title Genome Instability: A Common Link in Gulf War Illness Patients.
Publication Date Oct 2012
Media Count 8p
Personal Author H. Heng S. Chowdhury
Abstract The objective of this proposal is to determine whether there is a link between genome instability (reflected as elevated frequencies of NCCAs) and GWI. Patient samples (blood) are being directly analyzed using molecular cytogenetic analyses and gene expression studies. The central hypothesis of this proposal is that patients with GWI will display high levels of genome instability, particularly when challenged by various toxic agents, which can be stochastically linked to various molecular pathways and is the potential basis for diverse clinical symptoms that are seen in GWI.
Keywords Chromosomes
Genome
Gulfs
Hypotheses
Illness
Instability
Toxic agents


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57F - Cytology, Genetics, & Molecular Biology
Corporate Author Wayne State Univ., Detroit, MI.
Document Type Technical report
Title Note Revised annual rept. 30 Sep 2011-29 Sep 2012.
NTIS Issue Number 1315
Contract Number W81XWH-10-1-0541

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