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Accession Number ADA570536
Title Role of the Inflammasome in Asbestos-Induced Mesothelioma Formation.
Publication Date Oct 2012
Media Count 7p
Personal Author J. R. Testa
Abstract The investigations proposed in this idea award grant are aimed at addressing the requirement of asbestos-induced inflammation in the pathogenesis of malignant mesothelioma (MM). Cancer-related inflammation (CRI) within the tumor microenvironment contributes to tumor progression in many human malignancies. MM tumor samples have hallmarks of CRI including macrophage infiltration and inflammatory cytokine production. We intend to evaluate the role of asbestos-induced inflammation in the formation of MM by genetically and pharmacologically inhibiting inflammasome-mediated inflammation in mouse models of MM and determine whether this physiological response is required for tumor development. The overarching goal is to provide the first in vivoevidence of whether inflammation directly contributes to the development of asbestos-induced MM. The proposed investigations may also implicate inflammasome-mediated CRI as a potential target for the prevention or treatment of MM.
Keywords Asbestos
Connective tissue
Cytokines
Embryos
Epithelium
Inflammation
Macrophages
Neoplasms
Pathogenesis
Physiological effects


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Fox Chase Cancer Center, Philadelphia, PA.
Document Type Technical report
Title Note Annual rept.
NTIS Issue Number 1315
Contract Number W81XWH-10-1-0462

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