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Accession Number ADA570524
Title Role of Sleep Deprivation in Fear Conditioning and Extinction: Implications for Treatment of PTSD.
Publication Date Oct 2012
Media Count 5p
Personal Author S. P. Drummond
Abstract PTSD is a growing concern for both active duty personnel and Veterans. Fear conditioning is implicated in the development of PTSD, while successful acquisition, consolidation, and recall of extinction memory are implicated in both the natural reduction of initial PTSD symptoms and as the mechanism underlying the most successful treatment for PTSD, Prolonged Exposure. In animal models, sleep deprivation has been shown to impair extinction memory, although this has never been directly tested in humans. This project is the first to examine the role of sleep and sleep loss in acquisition, consolidation, and generalization of extinction memory in humans. The goal of the second year was to have a cumulative enrollment of 53 subjects in the protocol. This goal was successful met.
Keywords Acquisition
Active duty
Memory devices
Post traumatic stress disorder
Sleep deprivation

Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
57W - Stress Physiology
Corporate Author Veterans Medical Research Foundation, San Diego, CA.
Document Type Technical report
Title Note Annual rept. 1 Oct 2011-30 Sep 2012.
NTIS Issue Number 1315
Contract Number W81XWH-11-2-0001

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