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Accession Number ADA570264
Title Treatment of Adult Severe Traumatic Brain Injury Using Autologous Bone Marrow Mononuclear Cells.
Publication Date Jun 2012
Media Count 6p
Personal Author C. Cox
Abstract Traumatic brain injury (TBI) contributes to 50% of all trauma deaths. The mortality rate for adults following severe TBI (Glasgow Coma Scale < 9) is estimated to be 33%. There is currently no therapy to reverse the primary injury associated with TBI. Over the past 10 years there has been a growing body of literature supporting the use of various progenitor cell types to treat acute neurological injuries such as TBI and stroke. Neural stem cells (adult and embryonic), mesenchymal stromal and multipotent adult progenitor cells, and bone marrow mononucleaer cells (from which MSC and MAPCs are derived) have shown efficacy in preclinical models of TBI/stroke through various mechanisms, however, few groups believe that true neural replacement and integration are the putative mechanisms involved in the observed efficacy. More likely is that the progenitor cell populations are modifying the regional response to injury (inflammatory/reparative vs. regenerative), resulting in improved functional outcomes. Our primary hypothesis is that bone marrow mononuclear cell (BMMNC) autologous transplantation after TBI is safe (harvest and influsion related toxicity) after TBI. Our secondary hypothesis is that functional outcomes measures will improve after BMMNC influsion, (3) BMMNC fusion will reduce BBB permeability and BMMNC is neuroprotective and preserves grey matter and white matter volumes after TBI.
Keywords Bone marrow
Bone marrow mononuclear cells
Bones
Brain
Coma(Physiology)
Hospitals
Hypotheses
Infusions
Medicine
Monitoring
Mortality rate
Neurology
Patients
Plasmas(Physics)
Safety
Transplantation
Traumatic brain injuries
Wounds and injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Texas Univ. Health Science Center at Houston.
Document Type Technical report
Title Note Annual rept. 1 Jun 2011-31 May 2012.
NTIS Issue Number 1314
Contract Number W81XWH-11-1-0460

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