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Accession Number ADA570236
Title Does Childhood Diarrhea Influence Cognition Beyond the Diarrhea- Stunting Pathway.
Publication Date Oct 2012
Media Count 8p
Personal Author A. G. Lescano C. L. Walker L. Adair L. Lamberti R. L. Guerrant
Abstract Diarrhea is a leading cause of morbidity among children under 5 years of age in low-and middle-income countries yet the additional effects and sequelae, such as cognitive impairment associated with diarrhea, have not been quantified. We quantified the association between diarrhea prevalence and cognitive outcomes while controlling for linear growth in 4 study populations. Cognition was assessed using different methods across sites and was expressed in standardized units. We built linear regression models for each study with standardized cognitive score as the outcome and diarrhea prevalence as the main predictor variable. We then conducted meta-analyses of the regression coefficients to generate pooled estimates of the association between diarrhea prevalence and cognition whilst controlling for anthropometric status and other covariates. Diarrhea was not a significant predictor of cognitive score in any site in the regression models or in the meta-analyses (Coefficient = 0.07; 95% CI: -0.1, 0.2). The length for age Z-score was negatively related to cognition in all sites (0.18; 95% CI: 0.14, 0.21), with coefficients remarkably similar across sites (Coefficient Range: 0.168-0.186). We did not demonstrate an association between diarrhea and cognition with stunting included in the model. The links between diarrhea, stunting, and cognition provide additional rationale for accelerating interventions to reduce diarrhea.
Keywords Anthropometry
Cma(Comprehensive meta analysis)
Cognitive impairment
Diarrhea sequelae
Laz(Length for age)
Linear regression analysis
Low income countries
Middle income countries
Mortality rate
Regression analysis
Ses(Socioeconomic status)
Test methods

Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
Corporate Author Johns Hopkins Univ., Baltimore, MD. Bloomberg School of Public Health.
Document Type Journal article
Title Note Journal article.
NTIS Issue Number 1314
Contract Number N/A

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