Accession Number ADA570214
Title Harnessing the Power of Light to See and Treat Breast Cancer.
Publication Date Oct 2012
Media Count 60p
Personal Author N. Ramanujam
Abstract Our objective is to exploit the wealth of physiological, metabolic, morphological and molecular sources of optical contrast to develop novel strategies that focus on two breast cancer applications: tumor margin assessment and prediction of response to neo-adjuvant therapy. The proposed aims of this grant are expected to result in three major contributions. The first has the most immediate impact. An optically based strategy that can quickly and non-destructively detect positive tumor margins will decrease the need for re-excision surgery and thereby decrease the local recurrence rate and rate of distant metastases in women electing BCS. Gaining insight into the physiological, metabolic, morphological and molecular sources of heterogeneity within and among tumors and how they are modulated by therapy, drug resistance and metastatic potential will directly benefit prognostication, prediction of outcome and planning of cancer therapies. With these tools, clinicians and clinical researchers can get a better understanding of this disease and how it might react to a drug. Basic science researchers could use it as an informed approach to study tumor biology and assay the effect of novel therapeutic agents in vivo.
Keywords Breast cancer
Clinical medicine
Contrast
Drugs
Fiber-optic
Imaging
Impact
In vivo analysis
Metabolic diseases
Metastasis
Morphology
Neoplasms
Optical processing
Optical spectroscopy
Predictions
Screening
Therapy
Tools
Women


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Duke Univ., Durham, NC.
Document Type Technical report
Title Note Annual rept. 18 Sep 2011-17 Sep 2012.
NTIS Issue Number 1314
Contract Number W81XWH-09-1-0410

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