Accession Number ADA570213
Title Systemic and Local Vaccination against Breast Cancer with Minimum Autoimmune Sequelae.
Publication Date Oct 2012
Media Count 5p
Personal Author W. Wei
Abstract Our goal is to eliminate the tumor by vaccination and local ablation to render long-term immune protection without excessive autoimmune sequelae. Complimenting this regimen is systemic modulation of natural/induced Treg (iTreg) and intratumoral expression of immune augumenting cytokines. The two aims are to (1) Test the hypothesis that cryosurgery of cytokine enriched tumors amplifies Her-2 vaccine response, and (2) Test the hypothesis that disabling iTreg conversion enhances Her-2 immunity, not autoimmunity. In aim 1, we will measure immune response to tumor associated Her-2 by cryotherapy with and without DNA vaccination and the effect of intratumoral expression of cytokine. In aim 2, we will evaluate the degree of iTreg conversion in tumor bearing mice, measure Her-2 vaccine response in Her-2+TIEG1-/- mice which do not generate iTreg, and measure the induction of experimental autoimmune thyroiditis in iTreg deficient mice.
Keywords Ablation
Autoimmunization
Breast cancer
Cytokines
Deoxyribonucleic acids
Enrichment
Hypotheses
Immunity
Immunization
Induction systems
Neoplasms
Response(Biology)
Vaccines

 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author Wayne State Univ., Detroit, MI.
Document Type Technical report
Title Note Annual rept. 15 Sep 2011-14 Sep 2012.
NTIS Issue Number 1314
Contract Number W81XWH-10-1-0466

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