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Accession Number ADA570080
Title Neural Mechanisms Linking Mild Traumatic Brain Injury and Anxiety States in an Animal Model.
Publication Date Mar 2012
Media Count 60p
Personal Author G. Forster
Abstract Previous correlational studies suggest that mild traumatic brain injury (TBI) is associated with an increase in the prevalence of anxiety disorders, including posttraumatic stress disorder (PTSD). By using a relevant animal model, this research demonstrates that mild TBI can result in increased fear learning and anxiety states that mimic the symptoms of generalized anxiety disorder and PTSD. Furthermore, this research suggests that heightened fear and anxiety states following mild TBI may result from alterations to cell death and neuronal number in limbic brain regions such as the hippocampus and amygdala. Recent data generated from this project also suggests that experiencing psychosocial stress concurrent with mild brain injury results in serotonin dysfunction in the limbic system (particularly the hippocampus) and exacerbates anxiety states. Therefore, changes to limbic system function may underlie anxiety states that manifest following mild TBI and stress. Overall, the current rodent model of mild TBI appears to be a useful model to explore the neurobiological link between mild TBI and anxiety states, to allow better understanding of the consequences of war injuries like mild TBI, and to explore how such injury could be treated to prevent long-term disability.
Keywords Anxiety
Cells(Biology)
Incapacitation
Learning
Long range(Time)
Mental disorders
Nerve cells
Nervous system
Neurobiology
Order disorder transformations
Post traumatic stress disorder
Signs and symptoms
Social psychology
Stress(Psychology)
Traumatic brain injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
Corporate Author South Dakota Univ., Vermillion.
Document Type Technical report
Title Note Final rept. 12 Jul-28 Feb 2012.
NTIS Issue Number 1314
Contract Number W81XWH-10-1-0578

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