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Accession Number
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ADA567605
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Title
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Mammary Cancer and Activation of Transposable Elements.
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Publication Date
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Sep 2012
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Media Count
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8p
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Personal Author
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A. E. Peaston
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Abstract
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The purpose of this project is to investigate molecular events occurring in the preclinical stages of mammary cancer. Specifically, the project investigates the intersection between the development of genome demethylation, retrotransposon transcriptional activity, and retrotransposon- driven transcription of cellular genes in an engineered mouse model of mammary cancer. After accomplishing all the preliminary activity proposed in the Statement of Work, the project has completed with slight delay the mouse breeding for the project's Year One, and progress has been made in collecting material for planned molecular analyses. A series of technical and logistic problems delayed completing planned work on the molecular aspect of the project. However the problems have been solved and we are in a position to move forward with the molecular analyses within the next month, We believe that the eventual findings will provide insights into understanding the role of genome hypomethylation and expression of retrotransposons in cancer ontogeny, and may impact cancer prevention in the future.
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Keywords
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Anatomical models
Australia
Breast cancer
Breeding
Clinical medicine
Deep sequencing
Dna methylation
Epigenetic
Foreign reports
Genes
Mice
Molecules
Preclinical cancer
Preclinical stages
Preventive medicine
Retrotransposon
Transcription(Genetics)
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57E - Clinical Medicine
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Corporate Author
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Adelaide Univ. (Australia).
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Document Type
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Technical report
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Title Note
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Annual rept. 1 Sep 2011-31 Aug 2012.
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NTIS Issue Number
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1309
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Contract Number
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W81XWH-11-1-0401
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