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Accession Number
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ADA567595
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Title
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Prevention and Treatment of Noise-Induced Tinnitus.
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Publication Date
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Jul 2012
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Media Count
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10p
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Personal Author
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R. A. Altschuler
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Abstract
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Results from the first year of studies indicate that a 2 1/2 minute exposure to a small arms fire - like noise will induce tinnitus in some but not all of the noise-exposed rats. The noise exposure generates a hearing loss (as measured by the auditory brain stem response) ranging from mild to large that correlates with the amount of sensory cell (hair cell) loss induced by the noise. There can also be a loss of some of the auditory nerve terminals in the cochlear nucleus. Studies are now assessing the amount of loss of inner hair cell auditory nerve connections and looking for a correlation between each type of loss and the appearance of tinnitus. Studies are also now examining if antioxidant and anti-excitotoxicity therapeutics prior to the noise exposure will prevent the losses and reduce the incidence of tinnitus.
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Keywords
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Antioxidants
Auditory defects
Auditory nerve
Brain stem
Cochlear nerve
Exposure(Physiology)
Hair
Hearing
Losses
Nerves
Noise
Nuclei(Biology)
Preventive medicine
Senses(Physiology)
Small arms
Terminals
Tinnitus
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57A - Anatomy
57S - Physiology
57E - Clinical Medicine
57W - Stress Physiology
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Corporate Author
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Michigan Univ., Ann Arbor.
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Document Type
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Technical report
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Title Note
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Annual rept. 1 Jul 2011-30 Jun 2012.
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NTIS Issue Number
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1309
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Contract Number
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W81XWH-11-1-0414
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