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Accession Number ADA567468
Title T Cell Gene Therapy to Eradicate Disseminated Breast Cancers.
Publication Date May 2012
Media Count 52p
Personal Author R. P. Junghans
Abstract There is no cure for metastatic breast cancer, which kills 40,000 American women (and 500 men) each year: all presently available treatments are palliative. Gene therapy techniques are used to introduce chimeric immunoglobulin-T cell receptors (IgTCR) into autologous patient T cells to create designer T cells that redirect the T cell immune system in a new type of immuno-gene therapy against breast cancer. Designer T cells have been created against the carcinoembryonic antigen (CEA) that is prominently present on many metastatic breast tumors (30-60%). This exceeds the fraction that are Her2/neu overexpressing (20-25%), making CEA an even better immune target for attacking breast cancer. Building on a prior study of CEA designer T cells in breast and colon cancer, 2nd generation designer T cells were created by incorporating into the IgTCR a CD28 co-stimulation cassette that was shown to oppose activation-induced cell death (AICD) of the T cells after tumor contact. This advanced generation modification leads to improved designer T cell survival and improved anti-tumor potency in preclinical models. Although the 2nd generation designer T cells produce interleukin 2 (IL2) growth factor on contact with tumor, interleukin 2 (IL2) supplementation is anticipated still to be required for optimal clinical therapeutic effect. However, the CBER/FDA has mandated a Phase I.
Keywords Breast cancer
Clinical medicine
Colon cancer
Gene therapy
Mammary glands
T lymphocytes

Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Army Medical Research and Materiel Command (Provisional), Fort Detrick, MD.
Document Type Technical report
Title Note Annual rept. 1 May 2011-30 Apr 2012.
NTIS Issue Number 1309
Contract Number W81XWH-09-1-0039

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