|
Accession Number
|
ADA567351
|
|
Title
|
Mission Connect Mild TBI Translational Research Consortium.
|
|
Publication Date
|
Aug 2012
|
|
Media Count
|
13p
|
|
Personal Author
|
C. Robertson D. DeWitt
|
|
Abstract
|
The goals of this section are to characterize the physiological, histological, cerebral vascular and behavioral effects of blastinduced neurotrauma (BINT) and to determine the effects of hemorrhagic hypotension (HH) after mTBI on physiological and pathophysiological outcome. These studies indicated that BINT resulted in reduced CBF and increased CVR, observations consistent with the presence of cerebral vasospasm. Our results that BINT impaired vasodilatory responses to reduced intravascular pressure in middle cerebral arterial segments, suggest that blast injury may increase vulnerability of the brain to the effects of hemorrhagic hypotension. These results are consistent with our observations that rats subjected to mild fluid percussion TBI prior to severe HH exhibit higher numbers of injured hippocampal neurons than rats subjected to HH without mTBI.
|
|
Keywords
|
Arteries
Behavior
Blast
Cardiovascular system
Cerebrum
Hemorrhage
Hippocampus
Nerve cells
Traumatic brain injuries
Wounds and injuries
|
|
|
Source Agency
|
Non Paid ADAS
|
|
NTIS Subject Category
|
57A - Anatomy
57S - Physiology
57E - Clinical Medicine
|
|
Corporate Author
|
Baylor Coll. of Medicine, Houston, TX.
|
|
Document Type
|
Technical report
|
|
Title Note
|
Annual rept. 1 Aug 2011-31 Jul 2012.
|
|
NTIS Issue Number
|
1309
|
|
Contract Number
|
W81XWH-08-2-0132
|
