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Accession Number
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ADA567349
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Title
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Early Post Traumatic Seizures in Military Personnel Result in Long Term Disability.
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Publication Date
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Oct 2011
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Media Count
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8p
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Personal Author
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P. M. Vespa
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Abstract
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This study is predicated on substantial evidence that early post- traumatic seizures occur frequently and create a metabolic crisis that will lead to cell death of hippocampal tissue among persons who have sustained a traumatic brain injury (TBI). Our central hypothesis is that early post- traumatic seizures are acutely injurious due to increases in intracranial pressure and acute edema of the hippocampus leading to delayed long term hippocampal atrophy. This represents a unique translational hypothesis that we are uniquely qualified to study. In this study we plan to perform continuous EEG monitoring of military and civilian TBI patients for the initial 7 days after TBI to assess for non-convulsive seizures. This is followed by evaluating these same subjects at 6 months after injury by volumetric MRI of the hippocampus and cognitive testing to assess for disturbances of memory-related cognition and post-traumatic stress. We have begun to study civilian TBI patients in year 1 and have worked on establishing methodology and connectivity and IRB permission at military sites in year 1.
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Keywords
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Cognition
Convulsive disorders
Death
Edema
Electroencephalography
Hippocampus
Incapacitation
Metabolism
Physical disabilities
Seizures
Traumatic brain injuries
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57A - Anatomy
57S - Physiology
57E - Clinical Medicine
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Corporate Author
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California Univ., Los Angeles.
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Document Type
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Technical report
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Title Note
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Annual rept. 15 Sep 2010-14 Sep 2011.
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NTIS Issue Number
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1309
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Contract Number
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W81XWH-08-2-0699
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