Accession Number ADA567349
Title Early Post Traumatic Seizures in Military Personnel Result in Long Term Disability.
Publication Date Oct 2011
Media Count 8p
Personal Author P. M. Vespa
Abstract This study is predicated on substantial evidence that early post- traumatic seizures occur frequently and create a metabolic crisis that will lead to cell death of hippocampal tissue among persons who have sustained a traumatic brain injury (TBI). Our central hypothesis is that early post- traumatic seizures are acutely injurious due to increases in intracranial pressure and acute edema of the hippocampus leading to delayed long term hippocampal atrophy. This represents a unique translational hypothesis that we are uniquely qualified to study. In this study we plan to perform continuous EEG monitoring of military and civilian TBI patients for the initial 7 days after TBI to assess for non-convulsive seizures. This is followed by evaluating these same subjects at 6 months after injury by volumetric MRI of the hippocampus and cognitive testing to assess for disturbances of memory-related cognition and post-traumatic stress. We have begun to study civilian TBI patients in year 1 and have worked on establishing methodology and connectivity and IRB permission at military sites in year 1.
Keywords Cognition
Convulsive disorders
Death
Edema
Electroencephalography
Hippocampus
Incapacitation
Metabolism
Physical disabilities
Seizures
Traumatic brain injuries


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author California Univ., Los Angeles.
Document Type Technical report
Title Note Annual rept. 15 Sep 2010-14 Sep 2011.
NTIS Issue Number 1309
Contract Number W81XWH-08-2-0699

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