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Accession Number
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ADA567336
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Title
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Undiagnosed Small Fiber Polyneuropathy: Is it a Component of Gulf War Illness.
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Publication Date
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Jul 2012
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Media Count
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19p
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Personal Author
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A. L. Oaklander
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Abstract
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The term small-fiber polyneuropathy (SFPN) refers to body-wide dysfunction and degeneration of small-diameter axons that transmit pain and control the body s autonomic functions. The vague, widespread symptoms of SFPN overlap substantially with those of Gulf War Illness (GWI). We propose that there may be a SFPN component to GWI. To identify and apply the best tests to diagnose SFPN in Gulf War-ill veterans, we have been recruiting, screening, and testing normal control subjects and patients with definite SFPN to compare the sensitivity and specificity of the best current and potential new tests. We are now applying and comparing the best tests in Gulf War veterans with and without GWI to identify how often this diagnosable and treatable neurological illness is masquerading as GWI. By doing so, we will not only establish the relationship between GWI and SFPN, but will also determine which tests are the most diagnostically useful. This report summarizes progress against Specific Aims I and II of the basic statement of work.
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Keywords
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Axons
Biopsy
Fibers
Gulf war illness
Illness
Neurophysiology
Pain
Signs and symptoms
Skin(Anatomy)
Small-fiber polyneuropathy
Warfare
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57A - Anatomy
57S - Physiology
57E - Clinical Medicine
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Corporate Author
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Massachusetts General Hospital, Boston.
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Document Type
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Technical report
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Title Note
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Annual rept. 1 Jul 2011-30 Jun 2012.
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NTIS Issue Number
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1309
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Contract Number
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W81XWH-10-1-0534
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