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Accession Number ADA567286
Title Inhibition of Embryonic Genes to Control Colorectal Cancer Metastasis.
Publication Date Sep 2012
Media Count 68p
Personal Author J. Jessup
Abstract Embryonic core Transcription Factors (TFs), primarily the retrogene NanogP8, are the master regulators of stem cells in human Colorectal Carcinoma (CRC) and positively control neoplastic progression. The major goals of the application are to demonstrate that NanogP8 is expressed in human colorectal carcinoma (CRC) and that inhibition of expression of NanogP8 by lentiviral (LV) short hairpin (shRNA) will regress established human CRC liver xenografts in preclinical models. These data are necessary as proof of principle before we can progress to using LV shRNA in patients with advanced CRC in early phase trials.
Keywords Apoptosis
Cancer
Caspases
Colorectal carcinoma
Cores
Crc(Colorectal carcinoma)
Embryos
Genes
Growth(Physiology)
Lentiviral vector
Liver
Metastasis
Neoplasms
Patients
Regulators
Spheroids
Surgical transplantation
Tf(Transcription factors)
Tissue microarray
Xenografts

 
Source Agency Non Paid ADAS
NTIS Subject Category 57F - Cytology, Genetics, & Molecular Biology
57E - Clinical Medicine
Corporate Author Geneva Foundation, Lakewood, WA.
Document Type Technical report
Title Note Annual rept. 1 Sep 2011-31 Aug 2012.
NTIS Issue Number 1309
Contract Number W81XWH-11-1-0327

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