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Accession Number
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ADA567286
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Title
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Inhibition of Embryonic Genes to Control Colorectal Cancer Metastasis.
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Publication Date
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Sep 2012
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Media Count
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68p
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Personal Author
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J. Jessup
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Abstract
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Embryonic core Transcription Factors (TFs), primarily the retrogene NanogP8, are the master regulators of stem cells in human Colorectal Carcinoma (CRC) and positively control neoplastic progression. The major goals of the application are to demonstrate that NanogP8 is expressed in human colorectal carcinoma (CRC) and that inhibition of expression of NanogP8 by lentiviral (LV) short hairpin (shRNA) will regress established human CRC liver xenografts in preclinical models. These data are necessary as proof of principle before we can progress to using LV shRNA in patients with advanced CRC in early phase trials.
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Keywords
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Apoptosis
Cancer
Caspases
Colorectal carcinoma
Cores
Crc(Colorectal carcinoma)
Embryos
Genes
Growth(Physiology)
Lentiviral vector
Liver
Metastasis
Neoplasms
Patients
Regulators
Spheroids
Surgical transplantation
Tf(Transcription factors)
Tissue microarray
Xenografts
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57F - Cytology, Genetics, & Molecular Biology
57E - Clinical Medicine
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Corporate Author
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Geneva Foundation, Lakewood, WA.
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Document Type
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Technical report
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Title Note
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Annual rept. 1 Sep 2011-31 Aug 2012.
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NTIS Issue Number
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1309
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Contract Number
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W81XWH-11-1-0327
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