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Accession Number
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ADA566819
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Title
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Redox Regulation in Bone Marrow Failure.
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Publication Date
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Jun 2012
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Media Count
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18p
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Personal Author
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S. Pan
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Abstract
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Bone marrow failure is a group of hematopoietic stem cell disorders that affect one or more lineages of blood cells. Although the causes for bone marrow failure are complicated and not completely understood, oxidative stress has been recognized as a key contributor. Hematopoietic stem cells are highly sensitive to reactive oxygen species (ROS). Accumulation of ROS activates p38, shortens the life span of hematopoietic stem cells, disrupts the homeostasis of hematopoietic stem cells, and eventually causes bone marrow failure. The key role of p38 in the development of bone marrow failure has also been demonstrated by the finding that treating aplastic anemia patients with a p38 MAPK inhibitor can restore defective hematopoietic activity, suggesting the critical role of p38 in bone marrow failure.
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Keywords
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Accumulation
Blood cells
Bone marrow
Defects(Materials)
Hematopoietic cells
Inhibitors
Life span(Biology)
Stem cells
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57A - Anatomy
57S - Physiology
57E - Clinical Medicine
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Corporate Author
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Thomas Jefferson Univ., Philadelphia, PA.
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Document Type
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Technical report
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Title Note
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Final rept. 1 Apr 2010-31 May 2012.
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NTIS Issue Number
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1307
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Contract Number
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W81XWH-10-1-0207
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