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Accession Number ADA566777
Title Progression of Structural Change in the Breast Cancer Genome.
Publication Date Aug 2012
Media Count 19p
Personal Author R. Hartmaier
Abstract As our basic understanding of the human genome evolves, we are beginning to appreciate that it is not a static entity but rather a plastic one acquiring de novo mutations and structural charges. A number of recent studies suggest that breast cancer is initiated through disrupted DNA repair processes, leading to a destabilized genome, in turn promoting a heterogeneous primary lesion from which a/many subpopulation(s) acquire general or organ specific metastatic potential. I aim to identify and characterize the specific mutations that at acquired during breast cancer metastasis. To do this paired primary and metastatic beast cancer samples have been obtained and used for targeted and genome-wide analyses. Large insert mate-pair sequencing will commence in the coming months and will represent a wealth of data and will surely provide valuable results describing the process of breast cancer metastasis. Additionally, a homozygous deletion in NCOR2/SMRT was detected and is being further characterized and validated. Attached herein, I provide a detailed progress report for this project.
Keywords Breast cancer
Breast cancer strucural change
Copy number variant
Deoxyribonucleic acids
Genome
Heterogeneity
Metastasis
Mutations
Organs(Anatomy)
Sampling
Structural properties


 
Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57F - Cytology, Genetics, & Molecular Biology
Corporate Author Pittsburgh Univ., PA.
Document Type Technical report
Title Note Annual summary rept. 1 Aug 2011-31 Jul 2012.
NTIS Issue Number 1307
Contract Number W81XWH-11-1-0582

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