Accession Number ADA566767
Title Breast Cancer Stem Cells in Antiestrogen Resistance.
Publication Date Aug 2012
Media Count 33p
Personal Author G. Li H. Deng X. Zhang Z. Wang
Abstract Our research program is to study the role and underlying mechanisms of breast cancer stem/progenitor cells in antiestrogen resistance. One central subject is to understand the function of a novel estrogen receptor variant, ER- alpha 36, in antiestrogen resistance. In the past year, we have made significant progress towards accomplishment of the tasks proposed. We demonstrated that antiestrogen resistant ER-positive breast cancer cells contain high populations of stem/progenitor cells, and the stem/progenitor cells enriched from antiestrogen sensitive ER-positive breast cancer cells are refractory to and even stimulated by antiestrogens. The effects of antiestrogens on the ER-positive breast cancer stem/progenitor involve changes of both proliferation and differentiation. We also found that ER-alpha 36 plays an important role in positive regulation of both ER-positive and negative breast cancer stem/progenitor cells and contributes to the resistance of breast cancer stem/progenitor cells to antiestrogens presumably through mediating agonist activities of antiestrogens. Further study of the role and underlying mechanisms of breast cancer stem/progenitor cells in antiestrogen resistance will not only provide important information about the function of breast cancer stem/progenitor cells in development of antiestrogen resistance, but will also lay the foundation for development of novel therapeutic approaches to interfere with antiestrogen resistance.
Keywords Antiestrogen resistance
Breast cancer
Data bases
Estrogens
Risk
Stem cells


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Creighton Univ., Omaha, NE.
Document Type Technical report
Title Note Annual rept. 1 Aug 2011-31 Jul 2012.
NTIS Issue Number 1307
Contract Number W81XWH-11-1-0497

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