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Accession Number
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ADA566717
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Title
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Measuring Intracranial Pressure and Correlation with Severity of Blast Traumatic Brain Injury.
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Publication Date
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Oct 2011
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Media Count
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35p
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Personal Author
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P. VandeVord
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Abstract
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A greater understanding of the mechanism(s) of TBI due from overpressure exposure is critical to develop effective protection and treatments. Fundamental, yet unresolved, questions concern the mode of blast energy transfer to the brain as well as the consequent damage or disruptive mechanisms at the cellular level. The ultimate goal of this research effort is to determine the intracranial pressure (ICP) responses to blast exposure. The objective of this research is to understand how pressure is transmitted through the brain and ascertain the relationship between levels of pressure transmission with severity of brain injury. Several biomechanical parameters were investigated during this year of the proposal. We used a shock tube model in which instrumented animals were be subjected to a series of systematic shocktube studies of blast-stress transmission to the brain. We demonstrated by this series of tests that the brain-skull system is very sensitive to instrumentation location. Furthermore, we documented that the skull undergoes strain and deformation when exposed to the transient shock wave. Overall, the data key to determining the mechanism of blast energy transmission.
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Keywords
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Animal models
Biomechanics
Blast
Damage
Deformation
Energy transfer
Instrumentation
Measurement
Overpressure
Parameters
Shock tubes
Shock waves
Skull
Trauma
Traumatic brain injuries
Wounds and injuries
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57E - Clinical Medicine
72B - Algebra, Analysis, Geometry, & Mathematical Logic
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Corporate Author
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Army Medical Research and Materiel Command (Provisional), Fort Detrick, MD.
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Document Type
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Technical report
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Title Note
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Annual rept. 16 Seo 2919015 Sep 2011.
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NTIS Issue Number
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1307
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Contract Number
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W81XWH-08-2-0207
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