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Accession Number
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ADA566666
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Title
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Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury.
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Publication Date
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Jun 2011
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Media Count
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120p
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Personal Author
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A. Obenaus
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Abstract
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To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (NAD). Scope: In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. The effects of i) a prophylactic HBO strategy (pretreatment 3d X 1hr) prior to first mTBI and ii) the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of NAD right after the first mTBI impact will be evaluated using the MRI and histological biomarkers.
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Keywords
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Hbo( hyperbaric oxygen)
Histology
Hyperbaric conditions
Intranasal
Magnetic resonance imaging
Neuroprotective
Nicotinamide
Preventive medicine
Rats
Repetitive mild traumatic brain injury
Test and evaluation
Therapy
Tracer studies
Traumatic brain injuries
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57B - Biochemistry
57E - Clinical Medicine
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Corporate Author
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Loma Linda Univ., CA.
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Document Type
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Technical report
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Title Note
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Final rept. 1 Jun 2009-31 May 2011.
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NTIS Issue Number
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1307
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Contract Number
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W81XWH-09-1-0426
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