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Accession Number ADA566666
Title Neuroprotective Strategies after Repetitive Mild Traumatic Brain Injury.
Publication Date Jun 2011
Media Count 120p
Personal Author A. Obenaus
Abstract To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (NAD). Scope: In rat model of a repetitive mild cortical controlled injury, we investigated the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. The effects of i) a prophylactic HBO strategy (pretreatment 3d X 1hr) prior to first mTBI and ii) the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of NAD right after the first mTBI impact will be evaluated using the MRI and histological biomarkers.
Keywords Hbo( hyperbaric oxygen)
Histology
Hyperbaric conditions
Intranasal
Magnetic resonance imaging
Neuroprotective
Nicotinamide
Preventive medicine
Rats
Repetitive mild traumatic brain injury
Test and evaluation
Therapy
Tracer studies
Traumatic brain injuries

 
Source Agency Non Paid ADAS
NTIS Subject Category 57B - Biochemistry
57E - Clinical Medicine
Corporate Author Loma Linda Univ., CA.
Document Type Technical report
Title Note Final rept. 1 Jun 2009-31 May 2011.
NTIS Issue Number 1307
Contract Number W81XWH-09-1-0426

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