Accession Number ADA566658
Title Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury.
Publication Date Oct 2011
Media Count 9p
Personal Author P. Bergold
Abstract Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury (TBI). The grantee previously found screened that the combination of minocycline (MINO) and N-acetyl cysteine (NAC) synergistically improved brain function when dosed one hour following closed cortical impact (CCI) in rats. The overall objective of this proposal is that MINO/NAC synergistically improves brain function following TBI. Four tasks will be done to achieve this objective: (1) Differing doses of MINO/NAC will be tested for the ability to improve behavior and histology following moderate CCI. (2) MINO/NAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. (3) TBI is clinically heterogenous; MINO/NAC should restore brain function following an additional TBI model, lateral fluid percussion. (4) A restoration of cognitive function will be tested three months after CCI. The grantee has received both institutional and DoD approval for the animal experiments in this work and has trained a MD-Ph.D. candidate to perform these studies.
Keywords Animal tbi models
Behavioral restoration
Cci(Closed cortical impact)
Fda-approved drugs
Isobolistic analysis
Long-term efficacy
Military commanders
Nac(n-acetyl cysteine)
Synergistic drugs
Therapeutic window
Traumatic brain injuries

Source Agency Non Paid ADAS
NTIS Subject Category 57E - Clinical Medicine
57Q - Pharmacology & Pharmacological Chemistry
Corporate Author State Univ. of New York Downstate Medical Center, Brooklyn.
Document Type Technical report
Title Note Annual rept. 30 Sep 2010-29 Sep 2011.
NTIS Issue Number 1307
Contract Number W81XWH-10-2-0171

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