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Accession Number
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ADA566658
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Title
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Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury.
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Publication Date
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Oct 2011
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Media Count
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9p
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Personal Author
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P. Bergold
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Abstract
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Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury (TBI). The grantee previously found screened that the combination of minocycline (MINO) and N-acetyl cysteine (NAC) synergistically improved brain function when dosed one hour following closed cortical impact (CCI) in rats. The overall objective of this proposal is that MINO/NAC synergistically improves brain function following TBI. Four tasks will be done to achieve this objective: (1) Differing doses of MINO/NAC will be tested for the ability to improve behavior and histology following moderate CCI. (2) MINO/NAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. (3) TBI is clinically heterogenous; MINO/NAC should restore brain function following an additional TBI model, lateral fluid percussion. (4) A restoration of cognitive function will be tested three months after CCI. The grantee has received both institutional and DoD approval for the animal experiments in this work and has trained a MD-Ph.D. candidate to perform these studies.
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Keywords
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Animal tbi models
Behavioral restoration
Cci(Closed cortical impact)
Control
Drugs
Emergencies
Fda-approved drugs
International
Isobolistic analysis
Long-term efficacy
Military commanders
Mino(Minocycline)
Money
Nac(n-acetyl cysteine)
Reports
Synergistic drugs
Therapeutic window
Traumatic brain injuries
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57E - Clinical Medicine
57Q - Pharmacology & Pharmacological Chemistry
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Corporate Author
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State Univ. of New York Downstate Medical Center, Brooklyn.
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Document Type
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Technical report
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Title Note
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Annual rept. 30 Sep 2010-29 Sep 2011.
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NTIS Issue Number
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1307
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Contract Number
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W81XWH-10-2-0171
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