Documents in the NTIS Technical Reports collection are the results of federally funded research. They are directly submitted to or collected by NTIS from Federal agencies for permanent accessibility to industry, academia and the public.  Before purchasing from NTIS, you may want to check for free access from (1) the issuing organization's website; (2) the U.S. Government Printing Office's Federal Digital System website http://www.gpo.gov/fdsys; (3) the federal government Internet portal USA.gov; or (4) a web search conducted using a commercial search engine such as http://www.google.com.
Accession Number ADA566638
Title Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation.
Publication Date Jul 2012
Media Count 9p
Personal Author V. Seewaldt
Abstract Normal mammary gland homeostasis involves the coordinated regulation of cellular signaling networks. Current models suggest that that dysregulation of protein phosphorylation signaling occurs during breast cancer initiation. However, despite a wealth of mouse models and in vitro models of breast cancer, we have little prospective information on the biology of human breast cancer initiation. Here we aim to develop novel nanobiosensor technology to test live mammary epithelial cells taken directly from the breast of high-risk women for dysregulation of protein phosphorylation signaling. Under Specific Aim 1 will identify loss of normal protein phoshorylation signaling during breast cancer initiation. Under Specific Aim 2 we will develop targeted nanobiosensors to test real-time protein phosphorylation signaling in live Random Periareolar Fine Needle Aspriate (RPFNA) cells.
Keywords Breast cancer
Cells(Biology)
Epithelium
Homeostasis
Mammary glands
Phosphorylation


 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Duke Univ., Durham, NC.
Document Type Technical report
Title Note Final rept. 1 Jul 2009-30 Jun 2012.
NTIS Issue Number 1307
Contract Number W81XWH-09-1-0063

Science and Technology Highlights

See a sampling of the latest scientific, technical and engineering information from NTIS in the NTIS Technical Reports Newsletter

Acrobat Reader Mobile    Acrobat Reader