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Accession Number
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ADA566633
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Title
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Novel Therapeutic Targets for Chronic Migraine.
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Publication Date
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Sep 2012
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Media Count
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7p
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Personal Author
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A. Charles P. Goadsby
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Abstract
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Chronic migraine is a disabling disorder that affects millions of individuals worldwide, and may result from traumatic brain injury. The purpose of this study is to use rodent models of basic migraine mechanisms to characterize new potential treatments for chronic migraine. The scope of the research is to investigate multiple novel potential drug treatments on migraine- related brain excitability, pain-sensing mechanisms, and behavior. The major findings of the research in the first year of the project are that the medication amiloride inhibits the phenomenon of cortical spreading depression, a wave of activity that is believed to underlie the migraine aura. Amiloride also prevents the development chronic migraine-related hyperalgesia in mice. These results support the clinical investigation of amiloride and related drugs as treatments for chronic migraine. We have also found that the drug memantine inhibits cortical spreading depression, but acute treatment with memantine does not inhibit nociceptive signaling in the brainstem. These results are consistent with the potential efficacy of memantine as a preventive therapy, but not as an acute therapy for migraine. We have also found that delta opioid receptor agonists inhibit both cortical spreading depression and migraine related pain behaviors, also supporting the clinical investigation of these compounds. Overall, we have made significant progress in the characterization of novel potential therapies for chronic migraine.
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Keywords
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Behavior
Brain
Clinical medicine
Drugs
Headaches
Order disorder transformations
Pain
Prevention
Receptor sites(Physiology)
Wounds and injuries
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Source Agency
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Non Paid ADAS
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NTIS Subject Category
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57A - Anatomy
57Q - Pharmacology & Pharmacological Chemistry
57E - Clinical Medicine
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Corporate Author
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California Univ., Los Angeles.
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Document Type
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Technical report
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Title Note
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Annual rept. 1 Sep 2011-31 Aug 2012.
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NTIS Issue Number
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1307
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Contract Number
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W81XWH-11-1-0646
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