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Accession Number ADA566557
Title Dependency on Src-Family Kinases for Recurrence of Androgen-Independent Prostate Cancer.
Publication Date Aug 2012
Media Count 8p
Personal Author G. Smith
Abstract Prostate cancers that recur after so-called androgen ablation therapy ( CR-CaP ) are typically more aggressive, more likely to spread to local lymph nodes and bones, and less likely to respond to second-tier treatments, and therefore, contribute to significantly decreased patient survival. We posit that enzymes called Src-family kinases (SFK) are required for the progression to CR-CaP, and thus, targeting these enzymes should prevent CR-CaP formation to suppress their growth. We will use animal models of human and mouse CR-CaP in conjunction with genetic and biochemical experiments to show that SFK are critical to the formation of CR-CaP, and thus, are therapeutically targetable using SFK-specific drugs. Our important pre-clinical studies on the critical role played by SFK in CR-CaP disease will serve as the foundation to establish immediate clinical trials in which CaP patients are treated with drugs such as KX2-391 at the commencement of androgen-deprivation therapy.
Keywords Androgens
Enzymes
Foundations(Structures)
Genetics
Lymph nodes
Prostate cancer
Prostate gland
Therapy

 
Source Agency Non Paid ADAS
NTIS Subject Category 57A - Anatomy
57S - Physiology
57E - Clinical Medicine
Corporate Author Health Research, Inc., Buffalo, NY.
Document Type Technical report
Title Note Final rept. 15 Jul 2008-14 Jul 2012.
NTIS Issue Number 1307
Contract Number W81XWH-08-1-0027

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